Formamide → HCID 178484998、化合物

反応式

C(O[CH:5]([C:17](=O)[CH3:18])[CH2:6][S:7][CH2:8][CH2:9][NH:10][C:11]([NH:14][C:15]#[N:16])=[N:12][CH3:13])(=O)C.C([O-])([O-])OC.C([O-])=O.[NH4+:28].[CH:29]([NH2:31])=O>>[C:15]([NH:14][C:11]([NH:12][CH3:13])=[N:10][CH2:9][CH2:8][S:7][CH2:6][C:5]1[N:28]=[CH:29][NH:31][C:17]=1[CH3:18])#[N:16]

参加物

反応物 4

HCID 713Formamide

HCID 2723923Ammonium formate

HCID 14183543N-{2-(2-acetoxy-3-oxobutylthio)ethyl}-N'-cyano-N"-methylguanidine

HCID 53629101Methylorthoformate

生成物 1

HCID 178484998HCID 178484998、化合物収率 26%

反応条件

温度: 100 °C

実験手順

155 mg of N-{2-(2-acetoxy-3-oxobutylthio)ethyl-}-N'-cyano-N"-methylguanidine and 290 mg of methyl orthoformate was dissolved in 2.5 ml of formamide, and 170 mg of ammonium formate was added. The mixture was stirred at 100° C. for 2 hours. The reaction mixture was treated as in Referential Example 1 to give 36 mg (yield 26%) of the desired product as white crystals.

後処理

additionThe reaction mixture was treated as in Referential Example 1

出典と根拠

ORDレコード: ord-5c830ece92df4f2fb26b1aaf574a6f50
出典データセット: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04894475

反応ノート

読み込み中…