Acetyl chloride → Benzoic acid, 3-methoxy-4-methyl-, methyl ester

HRID 330142

反応式

HRID 330142 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[CH3:12])[C:6]([OH:8])=[O:7].[C:13](Cl)(=O)C>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[CH3:12])[C:6]([O:8][CH3:13])=[O:7]

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 815794-Methyl-m-anisic acid

生成物 1

HCID 591123Benzoic acid, 3-methoxy-4-methyl-, methyl ester収率 98%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 3-methoxy-4-methylbenzoic acid (6.0 g) in methanol (120 ml) was treated with acetyl chloride (6 ml) and stirred for 36 hours. The solution was evaporated. The residue was dissolved in methanol (100 ml) and the solution evaporated. This procedure was repeated to give methyl 3-methoxy-4-methylbenzoate (6.34 g, 98%) as a colorless oil; NMR (80 MHz, CDCl3): 2.2(s, 3H, CH3), 3.9(2s, 6H, 2×OCH3), 7.1(d, 1H), 7.5(m, 2H).

後処理

  1. customThe solution was evaporated
  2. dissolutionThe residue was dissolved in methanol (100 ml)
  3. customthe solution evaporated

出典と根拠

ORDレコード
ord-1337eee3efaa4aa7ba9e927d7718e6ca
出典データセット
uspto-grants-1990_01
特許番号
US04894386

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