Methanol → HCID 14882657、化合物

HRID 330194ノート

反応式

HRID 330194 の反応式
[CH2:1]([NH:5][C:6]([CH2:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH3:18])[CH:13]=[C:12]2[CH2:19][C:20]1[CH:29]=[CH:28][C:23]([C:24]([O:26]C)=[O:25])=[CH:22][C:21]=1[O:30][CH3:31])=[O:7])[CH2:2][CH2:3][CH3:4].CO.O1CCCC1.O.[OH-].[Li+]>O>[CH2:1]([NH:5][C:6]([CH2:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH3:18])[CH:13]=[C:12]2[CH2:19][C:20]1[CH:29]=[CH:28][C:23]([C:24]([OH:26])=[O:25])=[CH:22][C:21]=1[O:30][CH3:31])=[O:7])[CH2:2][CH2:3][CH3:4]

参加物

6

反応物 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 168937Lithium hydroxide, monohydrateHCID 19870596HCID 19870596、化合物

生成物 1

HCID 14882657HCID 14882657、化合物収率 94.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of methyl 4-[5-(butylcarbamoyl)methyl-1-methylindol-3-ylmethyl]-3-methoxybenzoate (0.23 g) in a combination of methanol (2.5 ml), tetrahydrofuran (2.5 ml), and water (1.5 ml) was treated with lithium hydroxide monohydrate (0.14 g). The mixture was stirred for 18 hr and the organic solvents evaporated. The resultant aqueous solution was acidified with 10% (v/v) hydrochloric acid. The ivory precipitate which formed was collected by filtration, washed with water, and dried under vacuum to give the title compound (0.21 g, 94%) as a pale pink powder: mp 92°-95°.

後処理

  1. customthe organic solvents evaporated
  2. customThe ivory precipitate which formed
  3. filtrationwas collected by filtration
  4. washwashed with water
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-f7bdf17d51784d3a8c3e2a5ea7487b34
出典データセット
uspto-grants-1990_01
特許番号
US04894386

反応ノート

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