Hydroxyamine hydrochloride → HCID 54444278、化合物
反応式
[CH3:1][O-:2].[Na+].[ClH:4].[NH2:5][OH:6].Cl[C:8]1[C:16]2OC=[C:13]([CH2:17][C:18]#[N:19])[C:12]=2[CH:11]=[CH:10][CH:9]=1>CO>[OH:6][N:5]=[C:18]([NH2:19])[CH2:17][C:13]1[C:12]2[CH:16]=[CH:8][CH:9]=[C:10]([Cl:4])[C:11]=2[O:2][CH:1]=1参加物
5
実験手順
A stirred mixture of NaOMe (25 wt % in MeOH, 11.3 mL, 0.0493 mol), MeOH (40 mL), and hydroxylamine hydrochloride (3.4 g, 0.0493 mol) was heated under reflux for 1 hour. 7-Chloro-3-benzofuranylacetonitrile (6.3 g, 0.0329 mol) and MeOH (15 mL) were added and heating was continued for 2 days. The mixture was concentrated, suspended in H2O, and filtered. The solid was triturated with ether to give the product (5.4 g, 73%) as a tan solid, m.p. 142°-145° C.
後処理
- temperaturewas heated
- temperatureunder reflux for 1 hour
- temperatureheating
- concentrationThe mixture was concentrated
- filtrationfiltered
- customThe solid was triturated with ether
出典と根拠
- ORDレコード
- ord-6076322030904576890bf19a81d0c79c
- 出典データセット
- uspto-grants-1990_01
- 特許番号
- US04895860
反応ノート
読み込み中…