(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chloride → 4-Chloro-3-hydroxybutyric acid ethyl ester, (3R)-

HRID 330385

反応式

HRID 330385 の反応式
CO[C@](C1C=CC=CC=1)(C(F)(F)F)C(Cl)=O.[Cl:17][CH2:18][CH:19]([OH:26])[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[Cl:17][CH2:18][C@H:19]([OH:26])[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]

参加物

3

反応物 2

HCID 3080792(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetyl chlorideHCID 4377704Butanoic acid, 4-chloro-3-hydroxy-, ethyl ester

生成物 1

HCID 27344454-Chloro-3-hydroxybutyric acid ethyl ester, (3R)-

実験手順

The resulting product was esterified with (R)α-methoxy-α-trifluoromethylphenylacetyl chloride, and the ester was analyzed by HPLC. From the area ratio of the chromatogram, the optical yield of the product was found to be 97.2% ee.

出典と根拠

ORDレコード
ord-e77df226a15942e0a532ac81d947a918
出典データセット
uspto-grants-1990_01
特許番号
US04895979

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