2-Propanethiol → 5-Isopropylthio-pyrrolidin-2-one
反応式
[OH:1][CH:2]1[NH:6][C:5](=O)[CH2:4][CH2:3]1.[CH3:8][CH:9]([SH:11])[CH3:10]>CCOCC>[CH:9]([S:11][CH:5]1[NH:6][C:2](=[O:1])[CH2:3][CH2:4]1)([CH3:10])[CH3:8]参加物
4
実験手順
A mixture of 9 g of 5-hydroxy-pyrrolidin-2-one in 40 cm3 of 2-propanethiol and 5 g of Amberlite resin IR 120 H is maintained for 80 hours at ambient temperature. After diluting with ether, filtering, and concentrating under reduced pressure, 8.5 g of the expected product is obtained. m.p. 77°-79° C., crystallized from isopropyl ether. m.p. 85°-87° C. after re-crystallization.
後処理
- filtrationfiltering
- concentrationconcentrating under reduced pressure
出典と根拠
- ORDレコード
- ord-305946d9a6094476881ff00344e5235f
- 出典データセット
- uspto-grants-1990_01
- 特許番号
- US04897414
反応ノート
読み込み中…