Ethyl 8-nitro-2-naphthoate → Ethyl 8-Amino-2-naphthoate

HRID 330506ノート

反応式

HRID 330506 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[CH:12]=[C:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:10]=[CH:9]2)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[CH:12]=[C:11]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH:10]=[CH:9]2

参加物

4

反応物 1

HCID 13368523Ethyl 8-nitro-2-naphthoate

生成物 1

HCID 14696377Ethyl 8-Amino-2-naphthoate収率 73.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

According to the procedure of W. Adcock, et al. Aust. J. Chem. 18, 1351 (1965), a suspension of ethyl 8-nitro-2-naphthoate (8.2 g, 0.033 mol) in ethanol (240 mL) was hydrogenated at 50 psi over 10% Pd/C (820 mg) for 4 hours. The mixture was filtered through Solka floc® and concentrated. Recrystallization of the residue from EtOH/H2O gave a yellow solid (5.2 g, 72%), m.p. 97°-98° C.

後処理

  1. filtrationThe mixture was filtered through Solka floc®
  2. concentrationconcentrated
  3. customRecrystallization of the residue from EtOH/H2O

出典と根拠

ORDレコード
ord-1980a0c21c7b4a8989b12396e3d2288c
出典データセット
uspto-grants-1990_01
特許番号
US04897405

反応ノート

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