Potassium bisulfate → 2,2-Diphenyl-1-(1-methyltetrazol-5-yl)ethene

HRID 330691ノート

反応式

HRID 330691 の反応式
[CH3:1][N:2]1[C:6]([CH2:7][C:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)O)=[N:5][N:4]=[N:3]1.OS([O-])(=O)=O.[K+]>>[C:16]1([C:8]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[CH:7][C:6]2[N:2]([CH3:1])[N:3]=[N:4][N:5]=2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

参加物

3

反応物 2

HCID 516920Potassium bisulfateHCID 147240362(1-Methyltetrazol-5-yl)-1,1-diphenylethanol

生成物 1

HCID 147240372,2-Diphenyl-1-(1-methyltetrazol-5-yl)ethene収率 85%

反応条件

温度
200 °C

実験手順

A mixture of 2(1-methyltetrazol-5-yl)-1,1-diphenylethanol (2.15 g; 7.68 mmole) and KHSO4 (300 mg) was heated at 200° C. for 20 minutes. The cooled mixture (50° C.) was triturated with CHCl3 (50 mL) and the organic solvent was decanted from the inorganic residue. Evaporation afforded the title compound as a cream solid (1.7 g; 85%); m.p.=147°-148° C. (crystallized from EtOAc-hexane). MS (CI): m/e=263 for (M+H)+ ;

後処理

  1. customThe cooled mixture (50° C.) was triturated with CHCl3 (50 mL)
  2. customthe organic solvent was decanted from the inorganic residue
  3. customEvaporation

出典と根拠

ORDレコード
ord-31445d89ad8f4bb2ad6e06d26487e39f
出典データセット
uspto-grants-1990_01
特許番号
US04897490

反応ノート

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