Diisopropylethylamine → HCID 86727989、化合物

HRID 330764ノート

反応式

HRID 330764 の反応式
[Br:1][C:2]1(F)[CH:7]=[CH:6][CH:5]=[CH:4][NH:3]1.Cl.[F:10][CH:11]([F:15])[CH2:12][NH:13][CH3:14].CCN(C(C)C)C(C)C>>[Br:1][C:2]1[N:3]=[C:4]([N:13]([CH2:12][CH:11]([F:15])[F:10])[CH3:14])[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 3

HCID 81531DiisopropylethylamineHCID 457923922,2-Difluoro-N-methylethan-1-amine--hydrogen chloride (1/1)HCID 67998121HCID 67998121、化合物

生成物 1

HCID 86727989HCID 86727989、化合物

実験手順

88.0 mg (0.50 mmol) 2-bromo-2-fluoropyridine, 78.9 mg (0.60 mmol) (2,2-difluoro-ethyl)-methyl-amine hydrochloride and 0.17 mL (1.00 mmol) DIPEA are stirred at 90° C. over night. The reaction is quenched by the addition of water and extracted with DCM. The combined org. layers are dried over MgSO4, filtered and the solvent is removend in vacuo.

後処理

  1. customThe reaction is quenched by the addition of water
  2. extractionextracted with DCM
  3. dry with materiallayers are dried over MgSO4
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-fa724f70c7c0437fb9c2c24912c397c4
出典データセット
uspto-grants-2014_11
特許番号
US08877741B2

反応ノート

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