Thionyl Chloride → 5-Bromo-2-(3-(chloromethyl)phenyl)pyrimidine

HRID 330804ノート

反応式

HRID 330804 の反応式
[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:8]2[CH:9]=[C:10]([CH2:14]O)[CH:11]=[CH:12][CH:13]=2)=[N:6][CH:7]=1.S(Cl)([Cl:18])=O>ClCCl>[Br:1][C:2]1[CH:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH2:14][Cl:18])[CH:9]=2)=[N:6][CH:7]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 59484879(3-(5-Bromopyrimidin-2-yl)phenyl)methanol

生成物 1

HCID 594380475-Bromo-2-(3-(chloromethyl)phenyl)pyrimidine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

80 g (302 mmol) of [3-(5-bromopyrimidin-2-yl)phenyl]methanol are suspended in 300 ml of dichloromethane, and 33 ml (453 mmol) of thionyl chloride are slowly added with cooling. The reaction mixture is stirred at room temperature for 3 h. The solvent is distilled off, co-evaporated 3 times with toluene and stirred with diethyl ether;

後処理

  1. temperaturewith cooling
  2. distillationThe solvent is distilled off
  3. stirringco-evaporated 3 times with toluene and stirred with diethyl ether

出典と根拠

ORDレコード
ord-7344beb402ae4a57b09d35d3069106fc
出典データセット
uspto-grants-2014_11
特許番号
US08877751B2

反応ノート

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