2-Bromo-1-(4-iodophenyl)ethanone → 1-(4-Iodo-phenyl)-2-(4-methyl-imidazol-1-yl)-ethanone

HRID 330818

反応式

HRID 330818 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][CH:6]=1)=[O:4].[CH3:12][C:13]1[N:14]=[CH:15][NH:16][CH:17]=1>C(#N)C>[I:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][N:16]2[CH:17]=[C:13]([CH3:12])[N:14]=[CH:15]2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 2565722-Bromo-1-(4-iodophenyl)ethanoneHCID 178418800HCID 178418800、化合物

生成物 1

HCID 666928261-(4-Iodo-phenyl)-2-(4-methyl-imidazol-1-yl)-ethanone

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To 2.50 g (7.69 mmol) 2-bromo-1-(4-iodo-phenyl)-ethanone in 30 mL ACN are added 1.90 g (23.1 mmol) 4-methylimidazole and the mixture is stirred at rt for 48 h. After that time, the solvent is evaporated and the residue is taken up in EtOAc. The mixture is washed with water and brine (2×) and the organic layer is dried over magnesium sulphate. The solvent is evaporated and the residue is recrystallized from diethyl ether to yield the desired product.

後処理

  1. customAfter that time, the solvent is evaporated
  2. washThe mixture is washed with water and brine (2×)
  3. dry with materialthe organic layer is dried over magnesium sulphate
  4. customThe solvent is evaporated
  5. customthe residue is recrystallized from diethyl ether

出典と根拠

ORDレコード
ord-44e203a0e8094400a366d51e98363dcc
出典データセット
uspto-grants-2014_11
特許番号
US08877754B2

関連ノート

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