2-Bromo-1-(4-iodophenyl)ethanone → 1-(4-Iodo-phenyl)-2-(4-methyl-imidazol-1-yl)-ethanone
反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][CH:6]=1)=[O:4].[CH3:12][C:13]1[N:14]=[CH:15][NH:16][CH:17]=1>C(#N)C>[I:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][N:16]2[CH:17]=[C:13]([CH3:12])[N:14]=[CH:15]2)=[CH:6][CH:7]=1参加物
4
実験手順
To 2.50 g (7.69 mmol) 2-bromo-1-(4-iodo-phenyl)-ethanone in 30 mL ACN are added 1.90 g (23.1 mmol) 4-methylimidazole and the mixture is stirred at rt for 48 h. After that time, the solvent is evaporated and the residue is taken up in EtOAc. The mixture is washed with water and brine (2×) and the organic layer is dried over magnesium sulphate. The solvent is evaporated and the residue is recrystallized from diethyl ether to yield the desired product.
後処理
- customAfter that time, the solvent is evaporated
- washThe mixture is washed with water and brine (2×)
- dry with materialthe organic layer is dried over magnesium sulphate
- customThe solvent is evaporated
- customthe residue is recrystallized from diethyl ether
出典と根拠
- ORDレコード
- ord-44e203a0e8094400a366d51e98363dcc
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08877754B2
反応ノート
読み込み中…