N-bromobutanimide → 3,4-Dibromo-1H-pyrrolo[2,3-b]pyridine
反応式
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[NH:8][CH:9]=[CH:10][C:3]=12.C1C(=O)N([Br:18])C(=O)C1>C(Cl)Cl>[Br:18][C:10]1[C:3]2[C:4](=[N:5][CH:6]=[CH:7][C:2]=2[Br:1])[NH:8][CH:9]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
A mixture of 4-bromo-1H-pyrrolo[2,3-b]pyridine (1.00 g, 5.08 mmol) and NBS (0.918 g, 5.16 mmol) in DCM (20.0 mL) was stirred at 0° C. for 1.5 hour. The resulting suspension was filtered, washed with DCM, residue collected, dried in a 50° C. oven overnight to afford the title compound (1.014 g). LCMS (A): m/z (M+H)+ 277, C7H4Br2N2 requires 276 (basic).
後処理
- filtrationThe resulting suspension was filtered
- washwashed with DCM, residue
- customcollected
- customdried in a 50° C. oven overnight
出典と根拠
- ORDレコード
- ord-6fdbfeff5fef4ede9cd78247ca27ff8a
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08877742B2
反応ノート
読み込み中…