N-Iodosuccinimide → 4-chloro-3-iodo-6-methyl-1H-pyrrolo[2,3-b]pyridine
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[NH:9][CH:10]=[CH:11][C:3]=12.C1C(=O)N([I:19])C(=O)C1>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]2[NH:9][CH:10]=[C:11]([I:19])[C:3]=12参加物
4
実験手順
To a stirred solution of 4-chloro-6-methyl-1H-pyrrolo[2,3-b]pyridine (4.06 g, 24.37 mmol) in DCM (80 mL) at 0° C., was added NIS (6.22 g, 27.6 mmol). The reaction mixture was then warmed to RT and stirred for 18 hours. The reaction mixture was then filtered (washed with excess DCM) to give the title compound (4.01 g). LCMS (A): m/z (M+H)+ 293, C8H6ClIN2 requires 292 (acidic).
後処理
- filtrationThe reaction mixture was then filtered
- wash(washed with excess DCM)
出典と根拠
- ORDレコード
- ord-d8ccce7840bd454ba996e1985f2eb47a
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08877742B2
反応ノート
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