Sodium Hydroxide → 1,2,3,4-Tetrahydro-1-naphthaleneacetic acid

HRID 331223ノート

反応式

HRID 331223 の反応式
[CH:1]1([CH2:11][C:12]([O:14]CC)=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[OH-].[Na+]>C(O)C>[CH:1]1([CH2:11][C:12]([OH:14])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 12322859Ethyl 2-(1,2,3,4-tetrahydronaphthalen-1-yl)acetate

生成物 1

HCID 128585751,2,3,4-Tetrahydro-1-naphthaleneacetic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of ethyl (1,2,3,4-tetrahydronaphthalen-1-yl)acetate (31.0 g) in ethanol (100 ml) was added sodium hydroxide (4N, 100 ml), and the mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated to a half volume under reduced pressure, and the residue was washed with ethyl acetate. The aqueous layer was acidified with dilute hydrochloric acid, and extracted with chloroform. The obtained organic layer was washed with water and saturated brine, dried over magnesium sulfate, and filtered. The solvent was evaporated under reduced pressure to give (1,2,3,4-tetrahydronaphthalen-1-yl)acetic acid.

後処理

  1. concentrationThe reaction mixture was concentrated to a half volume under reduced pressure
  2. washthe residue was washed with ethyl acetate
  3. extractionextracted with chloroform
  4. washThe obtained organic layer was washed with water and saturated brine
  5. dry with materialdried over magnesium sulfate
  6. filtrationfiltered
  7. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-7b4169e97d424a269bd33292661e084e
出典データセット
uspto-grants-2014_11
特許番号
US08877779B2

反応ノート

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