Ethanol → 4-(2-Fluorophenyl)butanoic acid

HRID 331240

反応式

HRID 331240 の反応式
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH:10](C(OC)=O)[C:11]([O:13]C)=[O:12].[OH-].[Na+].C(O)C>O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12]

参加物

5

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 68704652Dimethyl 2-[2-(2-fluorophenyl)ethyl]malonate

生成物 1

HCID 154910364-(2-Fluorophenyl)butanoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Dimethyl 2-[2-(2-fluorophenyl)ethyl]malonate, sodium hydroxide (22.7 g), ethanol (150 ml) and water (100 ml) were heated under reflux for 1.5 hr. The reaction mixture was concentrated under reduced pressure, and the residue was acidified with hydrochloric acid, and extracted with chloroform. The extract was washed with water and saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give 4-(2-fluorophenyl)butanoic acid.

後処理

  1. temperatureunder reflux for 1.5 hr
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. extractionextracted with chloroform
  4. washThe extract was washed with water and saturated brine
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-c468c92760b24edfb6d15c08c6986f80
出典データセット
uspto-grants-2014_11
特許番号
US08877779B2

関連ノート

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