Pyridine → 2,3-Dihydro-1-oxo-3-phenyl-1H-inden-6-yl acetate

HRID 331261ノート

反応式

HRID 331261 の反応式
[OH:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH2:7][C:8]2=[O:11])=[CH:4][CH:3]=1.N1C=CC=CC=1.[C:24](OC(=O)C)(=[O:26])[CH3:25]>C(Cl)Cl.CCOC(C)=O>[C:24]([O:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:7][C:8]2=[O:11])=[CH:4][CH:3]=1)(=[O:26])[CH3:25]

参加物

6

反応物 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 703075012,3-Dihydro-6-hydroxy-3-phenylinden-1-one

生成物 1

HCID 703172342,3-Dihydro-1-oxo-3-phenyl-1H-inden-6-yl acetate収率 77%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

2,3-Dihydro-6-hydroxy-3-phenylinden-1-one (22.5 g, 100 mmol) obtained in Step 2 was placed into a flask and dissolved in CH2Cl2 (300 mL). To the solution at 0° C., pyridine (40 mL, 5.0 eq) and acetic anhydride (47 mL, 5.0 eq) were added dropwise. The mixture was stirred for 8 h at room temperature. The reaction mixture was diluted with EtOAc and washed with H2O. The organic layer was dried over MgSO4 and concentrated in vacuo to give the desired product (20.0 g, 77%).

後処理

  1. washwashed with H2O
  2. dry with materialThe organic layer was dried over MgSO4
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-81ed5030ec0f49dc85e148b914b7501a
出典データセット
uspto-grants-2014_11
特許番号
US08877747B2

反応ノート

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