2-(2-Hydroxyethyl)pyridine → HCID 51001937、化合物

HRID 331312

反応式

HRID 331312 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[C:17]3[C:12](=[CH:13][C:14]([OH:18])=[CH:15][CH:16]=3)[C:11](=[O:19])[C:10]=2[C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[CH:5]=[C:6]([F:8])[CH:7]=1.BrC1C(=O)C2C(C=1C1C=CC=CC=1)=CC=C(O)C=2.[N:44]1[CH:49]=[CH:48][CH:47]=[CH:46][C:45]=1[CH2:50][CH2:51]O>>[F:8][C:6]1[CH:5]=[C:4]([C:9]2[C:17]3[C:12](=[CH:13][C:14]([O:18][CH2:51][CH2:50][C:45]4[CH:46]=[CH:47][CH:48]=[CH:49][N:44]=4)=[CH:15][CH:16]=3)[C:11](=[O:19])[C:10]=2[C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[CH:3]=[C:2]([F:1])[CH:7]=1

参加物

4

反応物 3

HCID 76752-(2-Hydroxyethyl)pyridineHCID 703061762-bromo-6-hydroxy-3-phenyl-1H-inden-1-oneHCID 703174323-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one

生成物 1

HCID 51001937HCID 51001937、化合物収率 45%

実験手順

The procedure of Step 6 of Example 1 was repeated except for using 3-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one obtained in Step 1 of Example 61 as a starting material instead of 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one, 2-(pyridin-2-yl)ethanol instead of 4-(2-hydroxyethyl)morpholine, being stirred for 7 d, and being purified by silica gel column chromatography (CH2Cl2/EtOAc=1:4) to obtain the title compound (45%).

後処理

  1. custombeing purified by silica gel column chromatography (CH2Cl2/EtOAc=1:4)

出典と根拠

ORDレコード
ord-818542feadf34dcea92d3f5a1793ef39
出典データセット
uspto-grants-2014_11
特許番号
US08877747B2

関連ノート

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