2-(2-Hydroxyethyl)pyridine → 3-(3,5-Difluorophenyl)-6-(2-(pyridin-2-yl)ethoxy)-2-(pyridin-3-yl)-1H-inden-1-one

関与物質

反応手順

The procedure of Step 6 of Example 1 was repeated except for using 3-(3,5-difluorophenyl)-6-hydroxy-2-(pyridin-3-yl)-1H-inden-1-one obtained in Step 1 of Example 61 as a starting material instead of 2-bromo-6-hydroxy-3-phenyl-1H-inden-1-one, 2-(pyridin-2-yl)ethanol instead of 4-(2-hydroxyethyl)morpholine, being stirred for 7 d, and being purified by silica gel column chromatography (CH2Cl2/EtOAc=1:4) to obtain the title compound (45%).

情報源と証拠