Piperazine → 6-Chloro-2-(piperazin-1-yl)-1,3-benzothiazole

HRID 33138

反応式

HRID 33138 の反応式
Cl[C:2]1[S:3][C:4]2[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:5]=2[N:6]=1.[NH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[S:3][C:4]=2[CH:10]=1

参加物

5

反応物 3

HCID 4837PiperazineHCID 11430Potassium CarbonateHCID 771762,6-Dichlorobenzothiazole

生成物 1

HCID 27465956-Chloro-2-(piperazin-1-yl)-1,3-benzothiazole

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 10 mmol 2,6-dichlorobenzothiazole, 12.3 mmol of piperazine and 20 mmol of potassium carbonate in 50 ml of acetonitrile was refluxed for 3 hours. The reaction mixture was concentrated and treated with 25 ml of water. Extraction with ethyl acetate, drying over magnesium sulfate, and evaporation of the solvent yielded the title compound as a colorless solid.

後処理

  1. temperaturewas refluxed for 3 hours
  2. concentrationThe reaction mixture was concentrated
  3. additiontreated with 25 ml of water
  4. extractionExtraction with ethyl acetate
  5. dry with materialdrying over magnesium sulfate, and evaporation of the solvent

出典と根拠

ORDレコード
ord-a26fb20dc43146a1a074d52e7333f8db
出典データセット
uspto-grants-2008_09
特許番号
US07429585B2

関連ノート

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