Piperazine → 6-Ethoxy-2-piperazin-1-yl-1,3-benzothiazole

HRID 33160ノート

反応式

HRID 33160 の反応式
Cl[C:2]1[S:3][C:4]2[CH:10]=[C:9]([O:11][CH2:12][CH3:13])[CH:8]=[CH:7][C:5]=2[N:6]=1.[NH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.C(N(CC)CC)C>O1CCCC1>[CH2:12]([O:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([N:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[S:3][C:4]=2[CH:10]=1)[CH3:13]

参加物

5

反応物 3

HCID 4837PiperazineHCID 8471TriethylamineHCID 3500152-Chloro-6-ethoxybenzo[d]thiazole

生成物 1

HCID 284708886-Ethoxy-2-piperazin-1-yl-1,3-benzothiazole

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
160 °C

実験手順

A mixture of 1.36 mmol 2-chloro-6-ethoxy-benzothiazole (CA=[79071-17-3]), 3.00 mmol of piperazine and 3.00 mmol of triethylamine in 5 ml of tetrahydrofuran in a sealed tube was heated at 160° C. for 5 min under microwave irradiation. The reaction mixture was concentrated, and the residue was purified by chromatography (SiO2, methanol/dichloromethane) to yield the title compound as a white solid.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. customthe residue was purified by chromatography (SiO2, methanol/dichloromethane)

出典と根拠

ORDレコード
ord-0dae454dc5b1428fb8d1e170ec03ec44
出典データセット
uspto-grants-2008_09
特許番号
US07429585B2

反応ノート

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