Potassium Carbonate → tert-Butyl 4-(quinolin-2-yl)piperazine-1-carboxylate

HRID 33165

反応式

HRID 33165 の反応式
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:14])[CH3:13].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[C:12]([O:16][C:17]([N:19]1[CH2:24][CH2:23][N:22]([C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH2:21][CH2:20]1)=[O:18])([CH3:15])([CH3:13])[CH3:14]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 119282-ChloroquinolineHCID 143452tert-Butyl piperazine-1-carboxylate

生成物 1

HCID 16117834tert-Butyl 4-(quinolin-2-yl)piperazine-1-carboxylate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 6.1 mmol 2-chloroquinoline, 6.7 mmol piperazine-1-carboxylic acid tert-butyl ester and 12.2 mmol potassium carbonate in 15 ml acetonitrile was refluxed overnight. The reaction mixture is concentrated, water is added and the compound extracted with ethyl acetate. Chromatography (SiO2; cyclohexane/ethyl acetate 9/1) gave the title compound as a colorless solid.

後処理

  1. temperaturewas refluxed overnight
  2. concentrationThe reaction mixture is concentrated
  3. additionwater is added
  4. extractionthe compound extracted with ethyl acetate

出典と根拠

ORDレコード
ord-a686448e25f6428e9d95799ac3023fb6
出典データセット
uspto-grants-2008_09
特許番号
US07429585B2

関連ノート

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