Hydrochloric Acid → 3-(3-Chlorophenyl)-5-methyl-1,2-oxazole-4-carboxylic acid
反応式
C([O:3][C:4]([C:6]1[C:7]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)=[N:8][O:9][C:10]=1[CH3:11])=[O:5])C.[OH-].[Na+].Cl.O>C(O)C>[Cl:18][C:14]1[CH:13]=[C:12]([C:7]2[C:6]([C:4]([OH:5])=[O:3])=[C:10]([CH3:11])[O:9][N:8]=2)[CH:17]=[CH:16][CH:15]=1参加物
6
実験手順
To a solution of 3-(3-chloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (9.1 g, 36 mmol) in ethanol (50 mL) was added aqueous sodium hydroxide (4 N, 10 mL). After heating at reflux for 1 h the mixture was cooled to room temperature and acidified with HCl (4 N, 10 mL) and water (10 mL) at 0° C. Purification by filtration and drying afforded the title compound (8.3 g, 97%) which was obtained as a white solid. Mp: 171-173° C.
後処理
- temperatureAfter heating
- temperatureat reflux for 1 h the mixture
- customPurification
- filtrationby filtration
- customdrying
出典と根拠
- ORDレコード
- ord-1524653471c1468596469c7e10737e69
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08877782B2
反応ノート
読み込み中…