Methanol → HCID 67204923、化合物

HRID 332074

反応式

HRID 332074 の反応式
[CH:1]1[CH:6]=[C:5]2/[C:7](/C(N[C:4]2=[CH:3][CH:2]=1)=O)=C/C1NC=CC=1.[CH3:17][C:18]([O:23]/N=C(/C(NCC=O)=O)\C1N=C(N)SC=1)([C:20]([OH:22])=O)[CH3:19].N1CC[CH2:41][CH2:40][CH2:39]1.[CH3:44][OH:45]>>[CH2:7]([O:45][CH2:44][CH2:19][C@@:18]1([CH3:17])[CH2:20][O:22][C:40]([CH3:41])([CH3:39])[O:23]1)[C:5]1[CH:6]=[CH:1][CH:2]=[CH:3][CH:4]=1

参加物

5

反応物 4

HCID 887MethanolHCID 8082PiperidineHCID 5908088(Z)-3-((1H-pyrrol-2-yl)methylene)indolin-2-oneHCID 15956689HCID 15956689、化合物

生成物 1

HCID 67204923HCID 67204923、化合物収率 81%

実験手順

To a stirred solution of oxindole 1 (4.19 g, 25 mmol) in methanol (50 mL) was added aldehyde 2 (3.96 g, 25 mmol) and piperidine (2.45 mL, 25 mmol). The reaction mixture was stirred at room temperature for 3 h and the yellow precipitate was collected, washed successively with methanol, hexanes, and ethyl ether and dried to give compound 3 (6.25 g, 81% yield).

後処理

  1. customthe yellow precipitate was collected
  2. washwashed successively with methanol, hexanes, and ethyl ether
  3. customdried

出典と根拠

ORDレコード
ord-f7e546787b0b48b78a554e039112702f
出典データセット
uspto-grants-2014_11
特許番号
US08877796B2

関連ノート

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