N-bromobutanimide → HCID 13037312、化合物

HRID 332105ノート

反応式

HRID 332105 の反応式
[Br:1]N1C(=O)CCC1=O.[CH:9]1[C:14]2[NH:15][C:16]3[C:21]([C:13]=2[CH:12]=[C:11]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[N:10]=1)=[CH:20][CH:19]=[CH:18][CH:17]=3>C(O)(=O)C>[Br:1][C:19]1[CH:20]=[C:21]2[C:16](=[CH:17][CH:18]=1)[NH:15][C:14]1[CH:9]=[N:10][C:11]([C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:12][C:13]2=1

参加物

4

反応物 2

HCID 67184N-bromobutanimideHCID 105078Ethyl Beta-Carboline-3-Carboxylate

生成物 1

HCID 13037312HCID 13037312、化合物収率 98%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Following a procedure in Chem. Bio. Chem, 2009, 10, 889-895, N-bromosuccinimide (37 mg, 0.208 mmol) was added to a solution of ethyl 9H-pyrido[3,4-b]indole-3-carboxylate (50 mg, 0.208 mmol) in acetic acid (1.5 ml) and stirred at room temperature. After 45 minutes the acetic acid was removed and the solid material was partitioned between EtOAc and NaHCO3. The organic layer was washed with water, brine, and dried over Na2SO4 to afford the desired compound in 98% yield.

後処理

  1. customAfter 45 minutes the acetic acid was removed
  2. customthe solid material was partitioned between EtOAc and NaHCO3
  3. washThe organic layer was washed with water, brine
  4. dry with materialdried over Na2SO4

出典と根拠

ORDレコード
ord-96c4d26eddfb46068f2006ad4dd2ed2b
出典データセット
uspto-grants-2014_11
特許番号
US08877797B2

反応ノート

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