Methanol → L-cysteic acid methyl ester hydrochloride

HRID 332609

反応式

HRID 332609 の反応式
[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][S:4](=[O:7])([OH:6])=[O:5].S(Cl)([Cl:13])=O.[CH3:15]O>>[ClH:13].[CH3:15][O:9][C:8](=[O:10])[C@H:2]([CH2:3][S:4](=[O:6])([OH:7])=[O:5])[NH2:1]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 72886L-Cysteic acid

生成物 1

HCID 86673321L-cysteic acid methyl ester hydrochloride収率 75%

実験手順

L-cysteic acid (300 mg, 1.77 mmol) was dissolved in methanol (12 mL), and thionyl chloride (2.5 mL, 34 mmol) was slowly added at 0° C. After stirring at room temperature overnight, the reaction mixture was concentrated under reduced pressure, and the obtained residue was suspended in diisopropyl ether. The suspension was filtered to give the title compound as white crystals (291 mg, 1.33 mmol, 75%).

後処理

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. filtrationThe suspension was filtered

出典と根拠

ORDレコード
ord-2050740cabfa4238933a646dca392ceb
出典データセット
uspto-grants-2014_11
特許番号
US08877805B2

関連ノート

読み込み中…