Hydrochloric Acid → N-allyl-L-aspartic acid di-tert-butyl ester hydrochloride

HRID 332630ノート

反応式

HRID 332630 の反応式
[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:3])[CH3:2].O.[ClH:22]>C(#N)C>[ClH:22].[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86673330N-allyl-L-aspartic acid di-tert-butyl ester

生成物 1

HCID 86673331N-allyl-L-aspartic acid di-tert-butyl ester hydrochloride収率 47%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

The obtained N-allyl-L-aspartic acid di-tert-butyl ester was dissolved in acetonitrile (10 mL), and water (17 mL) and 1N hydrochloric acid (1.8 mL, 1.8 mmol) were added. The solution was concentrated under reduced pressure and freeze-dried to give the title compound (0.54 g, 1.7 mmol, 47%).

後処理

  1. concentrationThe solution was concentrated under reduced pressure
  2. customfreeze-dried

出典と根拠

ORDレコード
ord-c243ac4b318141559b52fc26600362bd
出典データセット
uspto-grants-2014_11
特許番号
US08877805B2

反応ノート

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