Tert-butyl 2-diazoacetate → HCID 178496244、化合物

HRID 33265

反応式

HRID 33265 の反応式
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][CH2:7][O:8][CH2:9][C:10]#[CH:11].[C:12]([O:16][C:17](=[O:21])[CH:18]=[N+:19]=[N-:20])([CH3:15])([CH3:14])[CH3:13]>>[C:12]([O:16][C:17]([C:18]1[NH:19][N:20]=[C:10]([CH2:9][O:8][CH2:7][CH2:6][O:5][CH2:4][CH2:3][O:2][CH3:1])[CH:11]=1)=[O:21])([CH3:15])([CH3:14])[CH3:13]

参加物

3

反応物 2

HCID 5097903Tert-butyl 2-diazoacetateHCID 183816833-[2-(2-Methoxyethoxy)ethoxy]prop-1-yne

生成物 1

HCID 178496244HCID 178496244、化合物

反応条件

温度
70 °C

実験手順

To a solution containing approx. 2.5 g 3-[2-(2-Methoxy-ethoxy)-ethoxy]-propyne, 2.8 g Diazo-acetic acid tert-butyl ester were added and the mixture was heated to 70° C. for 5 days. Then the solution was concentrated under reduced pressure and directly purified by chromatography on silica eluting with a n-heptane/ethyl acetate gradient. Yield: 1.7 g.

後処理

  1. additionwere added
  2. concentrationThen the solution was concentrated under reduced pressure
  3. customdirectly purified by chromatography on silica eluting with a n-heptane/ethyl acetate gradient

出典と根拠

ORDレコード
ord-5dcdf0e1a84744839a7df22d5b6dc47e
出典データセット
uspto-grants-2008_09
特許番号
US07429581B2

関連ノート

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