Sodium Hydroxide → (Pyrimidin-4-yl)acetic acid

HRID 332991ノート

反応式

HRID 332991 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([O:10]CC)=[O:9])=[N:3][CH:2]=1.[OH-].[Na+]>C(O)C>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([OH:10])=[O:9])=[N:3][CH:2]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 20295406Ethyl 2-(pyrimidin-4-yl)acetate

生成物 1

HCID 21486925(Pyrimidin-4-yl)acetic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of ethyl 2-(pyrimidin-4-yl)acetate (Example 33b, 450 mg, 2.71 mmol) in ethanol (5 mL) was added 2N NaOH (2 mL) at room temperature under nitrogen. The reaction mixture was stirred at room temperature under nitrogen for 24 hours, concentrated under reduced pressure and suspended in ethanol. The solid was removed by vacuum filtration, and the filtrate was concentrated under reduced pressure, triturated with ethanol, concentrated again and carried onto the next step without further purification. MS 139 (MH+).

後処理

  1. concentrationconcentrated under reduced pressure
  2. customThe solid was removed by vacuum filtration
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customtriturated with ethanol
  5. concentrationconcentrated again
  6. customcarried onto the next step without further purification

出典と根拠

ORDレコード
ord-edb2da3827be45858058c420e306bbde
出典データセット
uspto-grants-2014_11
特許番号
US08877922B2

反応ノート

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