Potassium Cyanide → 2-(6-Fluoronaphthalen-2-yl)acetonitrile
反応式
Br[CH2:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([F:13])[CH:9]=2)[CH:4]=1.[C-:14]#[N:15].[K+]>CC#N>[F:13][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[CH:4]=[C:3]([CH2:2][C:14]#[N:15])[CH:12]=[CH:11]2参加物
4
実験手順
To a mixture of 2-bromomethyl-6-fluoro-naphthalene (1.5 g, 5.9 mmoL) in CH3CN (30 mL) was added KCN (1.16 g, 17.8 mmoL). The reaction mixture was heated at reflux for 6 h before being concentrated. To the residue was added diethyl ether (100 mL) and H2O (15 mL). The organic layer was separated, dried and concentrated. The resultant residue was purified by silica gel column chromatography (ethyl acetate/hexane=1:10) to afford the (6-fluoro-naphthalen-2-yl)-acetonitrile (0.88 g, 70%).
後処理
- temperatureThe reaction mixture was heated
- temperatureat reflux for 6 h
- concentrationbefore being concentrated
- additionTo the residue was added diethyl ether (100 mL) and H2O (15 mL)
- customThe organic layer was separated
- customdried
- concentrationconcentrated
- customThe resultant residue was purified by silica gel column chromatography (ethyl acetate/hexane=1:10)
出典と根拠
- ORDレコード
- ord-c8ed129c803a4f8e812b07320838c9a0
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08877975B2
反応ノート
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