Water → 1-(3,4-Dichlorophenyl)cyclopent-3-enecarbonitrile

HRID 333273ノート

反応式

HRID 333273 の反応式
[H-].[Na+].[Cl:3][C:4]1[CH:5]=[C:6]([CH2:11][C:12]#[N:13])[CH:7]=[CH:8][C:9]=1[Cl:10].Cl/[CH:15]=[CH:16]\[CH2:17][CH2:18]Cl.O>CS(C)=O>[Cl:3][C:4]1[CH:5]=[C:6]([C:11]2([C:12]#[N:13])[CH2:18][CH:17]=[CH:16][CH2:15]2)[CH:7]=[CH:8][C:9]=1[Cl:10]

参加物

6

反応物 4

HCID 962WaterHCID 24758Sodium hydrideHCID 76690(3,4-Dichlorophenyl)acetonitrileHCID 86614758HCID 86614758、化合物

生成物 1

HCID 589548471-(3,4-Dichlorophenyl)cyclopent-3-enecarbonitrile収率 43%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

To ice-cold DMSO (100 mL) was added 60% NaH (1.0 g, 2.3 eq) in portions. The cooling bath was removed and the solution was stirred at ambient temperature for ten minutes. A solution of 2-(3,4-dichlorophenyl)acetonitrile (2.0 g, 10.75 mmol) in DMSO (50 mL) was added. The brown solution was stirred for 15 minutes before cis-1,4-dichlorobutene (1.0 mL, 0.9 eq) was added. The reaction mixture was stirred overnight and was then poured into water. The product was extracted with DCM. The organic layer was washed with brine, evaporated, diluted with 50% ethyl acetate in hexanes, washed with water, and evaporated. The residual oil was separated on silica to give the nitrile (966 mg, 43%) as a pale-brown oil. GCMS Rt=10.8 min m/z=237 (M+). 1H NMR (CDCl3, δ): 7.51 (d, J=2.3 Hz, 1H), 7.39 (d, J=8.5 Hz, 1H), 7.28 (dd, J=2.3, 8.5 Hz, 1H), 5.79 (s, 2H), 3.27 (d, J=14.7 Hz, 2H), 2.87 (d, J=14.7 Hz, 2H). 13C NMR (CDCl3, δ): 141.9, 133.2, 132.1, 131.0, 128.5, 127.6, 125.0, 124.0, 48.4.

後処理

  1. customThe cooling bath was removed
  2. additionwas added
  3. stirringThe reaction mixture was stirred overnight
  4. extractionThe product was extracted with DCM
  5. washThe organic layer was washed with brine
  6. customevaporated
  7. additiondiluted with 50% ethyl acetate in hexanes
  8. washwashed with water
  9. customevaporated
  10. customThe residual oil was separated on silica

出典と根拠

ORDレコード
ord-671af1f8b754400da1bdc37835537aa4
出典データセット
uspto-grants-2014_11
特許番号
US08877975B2

反応ノート

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