Water → HCID 66987908、化合物

HRID 333416ノート

反応式

HRID 333416 の反応式
[NH2:1][C@@H:2]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1)[C:3]([O:5][CH3:6])=[O:4].O.Cl[C:18]([O:20][C:21]1[CH:26]=[CH:25][C:24]([N+:27]([O-:29])=[O:28])=[CH:23][CH:22]=1)=[O:19].C(N(C(C)C)CC)(C)C>ClCCl>[CH3:15][O:14][C:11]1[CH:10]=[CH:9][C:8]([CH2:7][C@H:2]([NH:1][C:18]([O:20][C:21]2[CH:22]=[CH:23][C:24]([N+:27]([O-:29])=[O:28])=[CH:25][CH:26]=2)=[O:19])[C:3]([O:5][CH3:6])=[O:4])=[CH:13][CH:12]=1

参加物

6

反応物 4

HCID 962Water2 回HCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 10856719O-Methyl-L-tyrosine methyl ester

生成物 1

HCID 66987908HCID 66987908、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1 g (4.8 mmol) of methyl(S)-2-amino-3-(4-methoxyphenyl)propionate (cf. preparation 2-1) is diluted in 30 mL of dichloromethane. The solution is cooled in a bath of cold water, and 1.4 g (7.2 mmol) of 4-nitrophenyl chloroformate and 1.2 mL (7.2 mmol) of diisopropylethylamine are then added. After warming to room temperature, the reaction medium is stirred for 2 hours. The solution is poured into water and then extracted with dichloromethane. The organic phase is dried and then evaporated. The crude product obtained is used in the following step without further purification.

後処理

  1. additionare then added
  2. extractionextracted with dichloromethane
  3. customThe organic phase is dried
  4. customevaporated

出典と根拠

ORDレコード
ord-9f75dd7f3bcd41df80f6a154aeb2408b
出典データセット
uspto-grants-2014_11
特許番号
US08877968B2

反応ノート

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