Trifluoroacetic acid → 4-(3-aminopropyl)-1H-imidazol-1-ium bis(trifluoroacetate)

HRID 333453

反応式

HRID 333453 の反応式
C([N:20]1[CH:24]=[C:23]([CH2:25][CH2:26][CH2:27][NH2:28])[N:22]=[CH:21]1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[F:29][C:30]([F:35])([F:34])[C:31]([OH:33])=[O:32]>ClCCl.CCOC(C)=O>[F:29][C:30]([F:35])([F:34])[C:31]([O-:33])=[O:32].[F:29][C:30]([F:35])([F:34])[C:31]([O-:33])=[O:32].[NH2:28][CH2:27][CH2:26][CH2:25][C:23]1[N:22]=[CH:21][NH2+:20][CH:24]=1.[NH2:28][CH2:27][CH2:26][CH2:25][C:23]1[N:22]=[CH:21][NH2+:20][CH:24]=1

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 153458253-(1-trityl-1H-imidazol-4-yl)propan-1-amine

生成物 1

HCID 866592094-(3-aminopropyl)-1H-imidazol-1-ium bis(trifluoroacetate)収率 61%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8857Ethyl Acetate溶媒

実験手順

0.5 g (1.4 mmol) of 3-(1-trityl-1H-imidazol-4-yl)propylamine is dissolved in 8 mL of dichloromethane with 2 mL of trifluoroacetic acid. After 2 hours, the medium is concentrated. The beige-coloured solid obtained is taken up in EtOAc and water, and the aqueous phase is then concentrated to dryness. 0.3 g of 4-(3-aminopropyl)-1H-imidazol-1-ium bis(trifluoroacetate) is obtained in a yield of 61%.

後処理

  1. concentrationthe medium is concentrated
  2. customThe beige-coloured solid obtained
  3. concentrationwater, and the aqueous phase is then concentrated to dryness

出典と根拠

ORDレコード
ord-e0835d61a944432aab08d260aafbdc27
出典データセット
uspto-grants-2014_11
特許番号
US08877968B2

関連ノート

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