Potassium Carbonate → Tert-butyl [3-methyl-3-(5-methyl-2-nitro-phenylamino)-butyl]-carbamate

HRID 33365

反応式

HRID 33365 の反応式
F[C:2]1[CH:3]=[C:4]([CH3:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9].[NH2:12][C:13]([CH3:25])([CH3:24])[CH2:14][CH2:15][NH:16][C:17](=[O:23])[O:18][C:19]([CH3:22])([CH3:21])[CH3:20].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:25][C:13]([NH:12][C:2]1[CH:3]=[C:4]([CH3:11])[CH:5]=[CH:6][C:7]=1[N+:8]([O-:10])=[O:9])([CH3:24])[CH2:14][CH2:15][NH:16][C:17](=[O:23])[O:18][C:19]([CH3:21])([CH3:20])[CH3:22]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 67966Benzene, 2-fluoro-4-methyl-1-nitro-HCID 45072486tert-butyl N-(3-amino-3-methylbutyl)carbamate

生成物 1

HCID 86603965Tert-butyl [3-methyl-3-(5-methyl-2-nitro-phenylamino)-butyl]-carbamate

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2.0 g (12.9 mmol) 3-fluoro-4-nitro-toluene, 2.6 g (13.0 mmol) tert-butyl (3-amino-3-methyl-butyl)-carbamate and 2.3 g (16.8 mmol) potassium carbonate are stirred overnight at ambient temperature in 20 mL DMF. The solvent is distilled off and the residue is combined with ethyl acetate. The mixture is washed repeatedly with water, dried with sodium sulphate and the solvent is eliminated. 4.8 g yellow oil. Mass spectroscopy: [M+H]+=338.

後処理

  1. distillationThe solvent is distilled off
  2. washThe mixture is washed repeatedly with water
  3. dry with materialdried with sodium sulphate

出典と根拠

ORDレコード
ord-0f0c11cfd1dc4952bf8cc9718579b0c3
出典データセット
uspto-grants-2008_09
特許番号
US07429583B2

関連ノート

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