2-Methoxybenzoyl chloride → HCID 59026631、化合物

HRID 333705ノート

反応式

HRID 333705 の反応式
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=2)[S:4][C:3]=1[C:14]#[N:15].[CH3:16][O:17][C:18]1[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=1[C:20](Cl)=[O:21]>N1C=CC=CC=1>[C:14]([C:3]1[S:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=2)=[CH:6][C:2]=1[NH:1][C:20](=[O:21])[C:19]1[CH:23]=[CH:24][CH:25]=[CH:26][C:18]=1[O:17][CH3:16])#[N:15]

参加物

4

反応物 2

HCID 889692-Methoxybenzoyl chlorideHCID 27358943-Amino-5-(4-fluorophenyl)thiophene-2-carbonitrile

生成物 1

HCID 59026631HCID 59026631、化合物収率 74%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of 3-amino-5-(4-fluorophenyl)thiophene-2-carbonitrile (2.0 g, 9.2 mmol) in pyridine (40 mL) was cooled in an ice bath, and 2-methoxybenzoyl chloride (1.2 mL, 9.2 mmol) was added dropwise. The cooling bath was removed, and the reaction was stirred for 16 h. The reaction was poured into water, and the resulting suspension was acidified with 1 M hydrochloric acid. The solid was filtered, washed with water, and dried under vacuum to give N-(2-cyano-5-(4-fluorophenyl)thiophen-3-yl)-2-methoxybenzamide (2.4 g, 74% yield).

後処理

  1. customThe cooling bath was removed
  2. additionThe reaction was poured into water
  3. filtrationThe solid was filtered
  4. washwashed with water
  5. customdried under vacuum

出典と根拠

ORDレコード
ord-30b0592c3f954f3bae612b0fd9ec7d79
出典データセット
uspto-grants-2014_11
特許番号
US08883781B2

反応ノート

読み込み中…