Methyl iodide → 6-Nitro-o-anisidine

HRID 33386

反応式

HRID 33386 の反応式
[OH-].[K+].[NH2:3][C:4]1[C:9]([N+:10]([O-:12])=[O:11])=[CH:8][CH:7]=[CH:6][C:5]=1[OH:13].I[CH3:15]>CN(C=O)C>[CH3:15][O:13][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([N+:10]([O-:12])=[O:11])[C:4]=1[NH2:3]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 14797Potassium HydroxideHCID 41154952-Amino-3-Nitrophenol

生成物 1

HCID 854916-Nitro-o-anisidine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

85% potassium hydroxide solution (11.7 g, 0.179 mol) is added to a solution of 25 g (0.162 mol) 2-amino-3-nitro-phenol in 200 mL DMF. Then 11.1 mL (0.178 mol) iodomethane are added dropwise and the mixture is stirred overnight at ambient temperature. The reaction mixture is poured onto ice and stirred for one hour. The precipitated product is filtered off, washed with water and dried.

後処理

  1. additionThe reaction mixture is poured onto ice
  2. stirringstirred for one hour
  3. filtrationThe precipitated product is filtered off
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-256aa94f9e5847479f45c40f7a09c03e
出典データセット
uspto-grants-2008_09
特許番号
US07429583B2

関連ノート

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