Methyl iodide → 6-Nitro-o-anisidine
反応式
[OH-].[K+].[NH2:3][C:4]1[C:9]([N+:10]([O-:12])=[O:11])=[CH:8][CH:7]=[CH:6][C:5]=1[OH:13].I[CH3:15]>CN(C=O)C>[CH3:15][O:13][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]([N+:10]([O-:12])=[O:11])[C:4]=1[NH2:3]参加物
5
実験手順
85% potassium hydroxide solution (11.7 g, 0.179 mol) is added to a solution of 25 g (0.162 mol) 2-amino-3-nitro-phenol in 200 mL DMF. Then 11.1 mL (0.178 mol) iodomethane are added dropwise and the mixture is stirred overnight at ambient temperature. The reaction mixture is poured onto ice and stirred for one hour. The precipitated product is filtered off, washed with water and dried.
後処理
- additionThe reaction mixture is poured onto ice
- stirringstirred for one hour
- filtrationThe precipitated product is filtered off
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-256aa94f9e5847479f45c40f7a09c03e
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07429583B2
反応ノート
読み込み中…