Triethylamine → HCID 57435847、化合物
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[NH:10][C:11](=[O:15])[O:12][CH2:13][CH3:14].C(N(CC)CC)C.Cl[C:24]([O:27]C(Cl)=O)(Cl)Cl>ClCCl>[CH3:9][O:8][C:4]1[C:3]2[N:10]([C:11]([O:12][CH2:13][CH3:14])=[O:15])[C:24](=[O:27])[NH:1][C:2]=2[CH:7]=[CH:6][CH:5]=1参加物
5
実験手順
13.0 g (0.062 mol) ethyl (2-amino-6-methoxy-phenyl)-carbamate and 10.3 mL (0.074 mol) triethylamine in 100 mL dichloromethane are added to a solution of 8.20 mL (0.068 mol) trichloromethylchloroformate in 50 mL dichloromethane while cooling with ice. After 4 hours stirring at ambient temperature the reaction mixture is poured onto ice and extracted with dichloromethane. The combined organic phases are washed with water, dried and freed from the solvent. The residue is stirred in diethyl ether.
後処理
- temperaturewhile cooling with ice
- additionis poured onto ice
- extractionextracted with dichloromethane
- washThe combined organic phases are washed with water
- customdried
- stirringThe residue is stirred in diethyl ether
出典と根拠
- ORDレコード
- ord-eaa408e68e90459c97843c8f9c84f0bf
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07429583B2
反応ノート
読み込み中…