tert-Butyl (3S)-3-(4-quinolylamino)pyrrolidine-1-carboxylate → N-[(3S)-Pyrrolidin-3-yl]quinolin-4-amine
反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([NH:11][C@H:12]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13]2)=[CH:3][CH:2]=1>ClCCl.FC(F)(F)C(O)=O>[NH:14]1[CH2:15][CH2:16][C@H:12]([NH:11][C:4]2[C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[N:1]=[CH:2][CH:3]=2)[CH2:13]1参加物
4
実験手順
tert-Butyl (3S)-3-(4-quinolylamino)pyrrolidine-1-carboxylate (231 mg, 0.68 mmol) was dissolved in a 1:1 mixture of dichloromethane and trifluoroacetic acid (2 ml) and stirred at room temperature for 15 minutes. The mixture was evaporated to dryness under reduced pressure and the residue obtained was used directly in the next step.
後処理
- customThe mixture was evaporated to dryness under reduced pressure
- customthe residue obtained
出典と根拠
- ORDレコード
- ord-2df75cc88bef4c0092b546ebb476418e
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08883791B2
反応ノート
読み込み中…