Sodium Hydroxide → (E)-4,4,5,5-tetrafluoropent-2-enoic acid

HRID 333977ノート

反応式

HRID 333977 の反応式
[F:1][C:2]([F:13])([CH:10]([F:12])[F:11])/[CH:3]=[CH:4]/[C:5]([O:7]CC)=[O:6].[OH-].[Na+]>C(O)C.O>[F:1][C:2]([F:13])([CH:10]([F:11])[F:12])/[CH:3]=[CH:4]/[C:5]([OH:7])=[O:6]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 86691166Ethyl (E)-4,4,5,5-tetrafluoropent-2-enoate

生成物 1

HCID 86691165(E)-4,4,5,5-tetrafluoropent-2-enoic acid収率 93%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

Ethyl (E)-4,4,5,5-tetrafluoropent-2-enoate (15.9 g, 0.08 mol) was dissolved in ethanol (30 ml), 4M NaOH was added (15 ml) and the mixture was stirred at room temperature overnight. The mixture was diluted with water, washed with ethylacetate, acidified with 1M HCl and extracted with ethyl acetate. The organic extract was dried over magnesium sulfate, the solvent was removed under reduced pressure. 12.8 g of a colourless oil were obtained (0.074 mmol, 93%). MS (ESI) m/z=170.9 [M−1]−.

後処理

  1. washwashed with ethylacetate
  2. extractionextracted with ethyl acetate
  3. extractionThe organic extract
  4. dry with materialwas dried over magnesium sulfate
  5. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-38df27479b75412a8427a10870eababf
出典データセット
uspto-grants-2014_11
特許番号
US08883791B2

反応ノート

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