HCID 86688251、化合物 → (3,3-Dimethyl-1-piperazinyl)(6-methoxy-2-pyridinyl)methanone

HRID 334021ノート

反応式

HRID 334021 の反応式
C(OC([N:11]1[CH2:16][CH2:15][N:14]([C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[N:20]=2)=[O:18])[CH2:13][C:12]1([CH3:28])[CH3:27])=O)C1C=CC=CC=1>[Pd].CO>[CH3:27][C:12]1([CH3:28])[NH:11][CH2:16][CH2:15][N:14]([C:17]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[N:20]=2)=[O:18])[CH2:13]1

参加物

4

反応物 1

HCID 86688251HCID 86688251、化合物

生成物 1

HCID 86688252(3,3-Dimethyl-1-piperazinyl)(6-methoxy-2-pyridinyl)methanone

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 1.10 g (2.87 mmol) 4-(6-methoxy-pyridine-2-carbonyl)-2,2-dimethyl-piperazine-1-carboxylic acid benzyl ester and 100 mg palladium on carbon in 20 mL methanol was hydrogenated at RT for 12 h at 3 bar. The catalyst was removed by filtration and the solvent was evaporated in vacuo.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-a19f4a0946e746b6bbd57e8f9b6473e4
出典データセット
uspto-grants-2014_11
特許番号
US08883789B2

反応ノート

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