Sodium Hydroxide → 1-Cyclopropyl-isoquinoline-3-carboxylic acid
反応式
C[O:2][C:3]([C:5]1[N:6]=[C:7]([CH:15]2[CH2:17][CH2:16]2)[C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:4].[OH-].[Na+]>CO>[CH:15]1([C:7]2[C:8]3[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=3)[CH:14]=[C:5]([C:3]([OH:4])=[O:2])[N:6]=2)[CH2:16][CH2:17]1参加物
4
実験手順
350 mg (1.54 mmol) 1-cyclopropyl-isoquinoline-3-carboxylic acid methyl ester was dissolved in 10 mL MeOH and treated with 2.50 mL 4 M aqueous NaOH solution at RT for 12 h. The solvent was removed by distillation, the residue taken up in water, acidified with 4 M aqueous hydrochlorid acid and extracted with EtOAc. The combined organic phases were dried over sodium sulfate, filtered and concentrated in vacuo.
後処理
- customThe solvent was removed by distillation
- extractionextracted with EtOAc
- dry with materialThe combined organic phases were dried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-75cc234d52b84dc7b7430ba2e8881658
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08883789B2
反応ノート
読み込み中…