Sodium Hydroxide → 3-(3-Fluorooxetan-3-yl)benzoic acid

HRID 334052ノート

反応式

HRID 334052 の反応式
C[O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2([F:14])[CH2:13][O:12][CH2:11]2)[CH:5]=1.[OH-].[Na+]>CO>[F:14][C:10]1([C:6]2[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=2)[C:3]([OH:15])=[O:2])[CH2:11][O:12][CH2:13]1

参加物

4

反応物 2

HCID 14798Sodium Hydroxide2 回HCID 86688281HCID 86688281、化合物

生成物 1

HCID 866882803-(3-Fluorooxetan-3-yl)benzoic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

200 mg (0.951 mmol) 3-(3-fluoro-oxetan-3-yl)-benzoic acid methyl ester was dissolved in 10 mL MeOH and treated with 0.40 mL 4 M aqueous NaOH solution at RT over the weekend. 0.20 mL 4 M aqueous NaOH solution was added and the mixture was stirred at 50° C. for 2 h. The reaction mixture was concentrated, acidified with 4 M aqueous hydrochlorid acid and stirred for 30 min at 0° C. The precipitate was filtered off, washed with water and dried.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. stirringstirred for 30 min at 0° C
  3. filtrationThe precipitate was filtered off
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-d2d351f3add64bf09af4f9defdceb97f
出典データセット
uspto-grants-2014_11
特許番号
US08883789B2

反応ノート

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