Methanol → 2-Chloro-6-methoxypyridin-4-amine

HRID 334054

反応式

HRID 334054 の反応式
[Na].[Cl:2][C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[C:5](Cl)[N:4]=1.[CH3:11][OH:12]>>[Cl:2][C:3]1[CH:8]=[C:7]([NH2:9])[CH:6]=[C:5]([O:12][CH3:11])[N:4]=1

参加物

4

反応物 3

HCID 887MethanolHCID 1376524-Amino-2,6-dichloropyridineHCID 5360545Sodium

生成物 1

HCID 713025122-Chloro-6-methoxypyridin-4-amine

反応条件

温度
150 °C

実験手順

To a solution of 1.84 g (44.0 mmol) sodium in 40 mL MeOH was added 6.72 g (40.0 mmol) 2,6-dichloro-pyridin-4-ylamine. The reaction mixture was stirred at 150° C. for 30 min under microwave irradiation. The solvent was evaporated and ice water was added. The precipitate was filtered off, washed with water and dried.

後処理

  1. customThe solvent was evaporated
  2. additionice water was added
  3. filtrationThe precipitate was filtered off
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-d4a7b52437e44155b9cd4be82e8585e1
出典データセット
uspto-grants-2014_11
特許番号
US08883789B2

関連ノート

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