Sodium Hydroxide → HCID 84696473、化合物

HRID 334059ノート

反応式

HRID 334059 の反応式
C[O:2][C:3]([C:5]1[N:6]=[C:7]([O:17][CH3:18])[C:8]2[C:13]([CH:14]=1)=[CH:12][C:11]([O:15][CH3:16])=[CH:10][CH:9]=2)=[O:4].[OH-].[Na+]>CO>[CH3:18][O:17][C:7]1[C:8]2[C:13](=[CH:12][C:11]([O:15][CH3:16])=[CH:10][CH:9]=2)[CH:14]=[C:5]([C:3]([OH:4])=[O:2])[N:6]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 866882833-Isoquinolinecarboxylic acid, 1,6-dimethoxy-, methyl ester

生成物 1

HCID 84696473HCID 84696473、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

500 mg (2.02 mmol) 1,6-dimethoxy-isoquinoline-3-carboxylic acid methyl ester was dissolved in 20 mL MeOH and treated with 2.50 mL 4 M aqueous NaOH solution at RT for 12 h. The solvent was removed by distillation, the residue taken up in water and acidified with 4 M aqueous hydrochlorid acid. The precipitate was filtered off, washed with water and purified by HPLC.

後処理

  1. customThe solvent was removed by distillation
  2. filtrationThe precipitate was filtered off
  3. washwashed with water
  4. custompurified by HPLC

出典と根拠

ORDレコード
ord-9c1a3869d16e4b3b965d2666b7d5a2aa
出典データセット
uspto-grants-2014_11
特許番号
US08883789B2

反応ノート

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