Methanol → 3-Chloro-6-fluoro-1-methoxyisoquinoline
反応式
[Na].Cl[C:3]1[C:12]2[C:7](=[CH:8][C:9]([F:13])=[CH:10][CH:11]=2)[CH:6]=[C:5]([Cl:14])[N:4]=1.[CH3:15][OH:16]>>[Cl:14][C:5]1[N:4]=[C:3]([O:16][CH3:15])[C:12]2[C:7]([CH:6]=1)=[CH:8][C:9]([F:13])=[CH:10][CH:11]=2参加物
4
反応条件
- 温度
- 70 °C
実験手順
To a solution of 125 mg (3.00 mmol) sodium in 40 mL MeOH was added 668 mg (3.00 mmol) 1,3-dichloro-6-fluoro-isoquinoline. The reaction mixture was stirred at 70° C. for 30 min. The solvent was removed by distillation and the residue diluted with ice water. The precipitate was filtered off, washed with water and dried.
後処理
- customThe solvent was removed by distillation
- additionthe residue diluted with ice water
- filtrationThe precipitate was filtered off
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-c8d994cb1d8a44069c3b782386cadbb7
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08883789B2
反応ノート
読み込み中…