Trifluoroacetic acid → (2,2-Dimethyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone trifluoroacetate
反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[N:17]=2)=[O:15])[C:10]([CH3:25])([CH3:24])[CH2:9]1)=O)(C)(C)C.[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27]>C(Cl)Cl>[F:29][C:28]([F:31])([F:30])[C:26]([OH:32])=[O:27].[CH3:24][C:10]1([CH3:25])[CH2:9][NH:8][CH2:13][CH2:12][N:11]1[C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[N:17]=1)=[O:15]参加物
4
実験手順
A mixture of 780 mg (2.23 mmol) 4-(6-methoxy-pyridine-2-carbonyl)-3,3-dimethyl-piperazine-1-carboxylic acid tert-butyl ester and 2.00 mL (25.9 mmol) TFA in 10 mL DCM was stirred at RT for 12 h. The solvent was evaporated and the residue triturated with diethyl ether. The precipitate was filtered off, washed with diethyl ether and dried.