Methoxyacetone → HCID 86688304、化合物

HRID 334081

反応式

HRID 334081 の反応式
[CH3:1][O:2][CH2:3][C:4](=O)[CH3:5].[CH2:7]([O:9][C:10](=[O:20])[CH2:11][NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH3:8].C[Si]([C:25]#[N:26])(C)C>C(O)(=O)C>[CH2:7]([O:9][C:10](=[O:20])[CH2:11][N:12]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:4]([C:25]#[N:26])([CH3:5])[CH2:3][O:2][CH3:1])[CH3:8]

参加物

5

反応物 3

HCID 22172MethoxyacetoneHCID 80908N-Benzylglycine ethyl esterHCID 82115Trimethylsilyl cyanide

生成物 1

HCID 86688304HCID 86688304、化合物

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
80 °C

実験手順

To a mixture of 500 μL (5.43 mmol) methoxyacetone and 1.05 g (5.43 mmol) N-benzylglycine ethyl ester in 2.0 mL acetic acid was added 780 μl (6.18 mmol) trimethylsilyl cyanide dropwise. The resulting mixture was stirred at 80° C. for 30 min and then poured into ice water. The water was decanted and the oily residue was triturated with DIPE. The precipitate was filtered off and the solvent was washed with saturated aqueous NaHCO3 solution, dried over sodium sulfate, filtered and concentrated in vacuo.

後処理

  1. customThe water was decanted
  2. customthe oily residue was triturated with DIPE
  3. filtrationThe precipitate was filtered off
  4. washthe solvent was washed with saturated aqueous NaHCO3 solution
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-8ec03467cdcf4320a65d9f7ac1eee16f
出典データセット
uspto-grants-2014_11
特許番号
US08883789B2

関連ノート

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