(4-Benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone → (3-Methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

HRID 334085ノート

反応式

HRID 334085 の反応式
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[N:17]=2)=[O:15])[CH2:10][C:9]1([CH2:25][O:26][CH3:27])[CH3:24])C1C=CC=CC=1>[Pd].CO>[CH3:27][O:26][CH2:25][C:9]1([CH3:24])[NH:8][CH2:13][CH2:12][N:11]([C:14]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[N:17]=2)=[O:15])[CH2:10]1

参加物

4

反応物 1

HCID 86688307(4-Benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

生成物 1

HCID 86688308(3-Methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 170 mg (414 μmol, purity: 90%) (4-benzyl-3-methoxymethyl-3-methyl-piperazin-1-yl)-(6-methoxy-pyridin-2-yl)-methanone and 20 mg palladium on carbon in 10 mL methanol was hydrogenated at 50° C. for 12 h at 50 psi. The catalyst was removed by filtration and the solvent was evaporated in vacuo.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated in vacuo

出典と根拠

ORDレコード
ord-1bd3ef443a624d2e966e9d99bac45393
出典データセット
uspto-grants-2014_11
特許番号
US08883789B2

反応ノート

読み込み中…