Bromine → 7-Bromothieno[3,2-d]pyrimidine-2,4(1h,3h)-dione

HRID 334151

反応式

HRID 334151 の反応式
[NH:1]1[C:6]2[CH:7]=[CH:8][S:9][C:5]=2[C:4](=[O:10])[NH:3][C:2]1=[O:11].[Br:12]Br>C(O)(=O)C>[Br:12][C:7]1[C:6]2[NH:1][C:2](=[O:11])[NH:3][C:4](=[O:10])[C:5]=2[S:9][CH:8]=1

参加物

4

反応物 2

HCID 24408BromineHCID 7059273Thieno(3,2-d)pyrimidine-2,4(1H,3H)-dione

生成物 1

HCID 183264277-Bromothieno[3,2-d]pyrimidine-2,4(1h,3h)-dione収率 60%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
80 °C

実験手順

Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (10.38 g, 61.72 mmol) was dissolved in acetic acid (230 mL) and Bromine (11.13 mL, 216 mmol) was added. The reaction was heated at 80° C. for 3.5 h. Complete reaction was confirmed by LCMS. The reaction mixture was poured onto ice water slowly and filtered off the precipitate which was dried overnight under vacuum to give 7-bromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (9.1 g, 60% yield)

後処理

  1. customComplete reaction
  2. additionThe reaction mixture was poured onto ice water slowly
  3. filtrationfiltered off the precipitate which
  4. customwas dried overnight under vacuum

出典と根拠

ORDレコード
ord-2b62709c92634f6d93054bc037e3db69
出典データセット
uspto-grants-2014_11
特許番号
US08883799B2

関連ノート

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