2-Nitro-6-(pyridin-2-yl)aniline → 3-(Pyridin-2-yl)benzene-1,2-diamine

HRID 334492ノート

反応式

HRID 334492 の反応式
[N+:1]([C:4]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[C:5]=1[NH2:6])([O-])=O>CCOC(C)=O.[Pd]>[N:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[C:7]1[CH:8]=[CH:9][CH:10]=[C:4]([NH2:1])[C:5]=1[NH2:6]

参加物

4

反応物 1

HCID 130010352-Nitro-6-(pyridin-2-yl)aniline

生成物 1

HCID 224661493-(Pyridin-2-yl)benzene-1,2-diamine収率 103,000%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 2-nitro-6-(pyridin-2-yl)aniline (XCIX) (2.4 g, 0.01 mmol, 1 eq) in EtOAc (350 mL) was added Pd/C (1 g) and the mixture was stirred at room temperature overnight, filtered and then concentrated in vacuo, to give 3-(pyridin-2-yl)benzene-1,2-diamine (1.9 g, 10.3 mmol, 89% yield) as a yellow oil. ESIMS found for C11H11N3 m/z 186 (M+H).

後処理

  1. filtrationfiltered
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-b7d4ad900fd64b83ac3ac7883e5a67fb
出典データセット
uspto-grants-2014_11
特許番号
US08883822B2

反応ノート

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