Benzyl chloroformate → HCID 16778897、化合物

HRID 334525ノート

反応式

HRID 334525 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:13]=[C:14]([Cl:16])[CH:15]=1)[C:5]([NH:7][NH:8][C:9](=[O:12])[CH2:10][Cl:11])=O.C(Cl)(OCC1C=CC=CC=1)=O>C(Cl)Cl>[Cl:11][CH2:10][C:9]1[O:12][C:5]([C:4]2[CH:3]=[C:2]([Cl:1])[CH:15]=[C:14]([Cl:16])[CH:13]=2)=[N:7][N:8]=1

参加物

4

反応物 2

HCID 10387Benzyl chloroformateHCID 13365860HCID 13365860、化合物2 回

生成物 1

HCID 16778897HCID 16778897、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of compound 6 (1.0 g, 6.36 mmol) and Et3 N (0.96 g, 9.50 mmol) in DCM, was added CbzCl (1.30 g, 7.64 mmol) slowly. The mixture was stirred at ambient temperature overnight. Then TLC showed-compound 6 had disappeared. The mixture was washed with brine, dried with Na2SO4 and concentrated to give crude product 7 as a colorless oil which was used in the next step without any purification.

後処理

  1. washThe mixture was washed with brine
  2. dry with materialdried with Na2SO4
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-0cc6f20d13ab4dbe9ad7ef603987e5c1
出典データセット
uspto-grants-2014_11
特許番号
US08883827B2

反応ノート

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